Research Overview

Working in Utah has several distinct advantages for Axial Biotech’s programs. More human disease genes have been mapped and discovered using the exceptional population of the Intermountain West than with any other population. No other company or research institution in our field has access to Utah ’s unique large families and multi-generational genealogical records which provide an unparalleled resource for genetic research into spinal disorders. Using these resources, Axial Biotech has developed an extensive collection of DNA samples correlated with medical records in the focused areas of our product development programs. Some of the reasons for the incredible success of genetic research in Utah are:

  • Utah has, on average, larger family sizes and a significantly higher birth rate than other states.

The average family in Utah today has five children; a generation ago the average number of children was 8; before that it was 10. Utah has experienced incredibly fast population expansion over the past 150 years which creates an ideal environment of extended families of multiple generations to quickly determine heritability of complex diseases.

  • Fewer errors occur when studying extended families in Utah because the incidence of “non-paternity” (unknown or incorrectly attributed fathers) is lower.

(<1% among Utah residents verses approximately 10% for the US ).

  • Utah is genetically representative of the world at large.

While the population is predominately Caucasian, all ethnic and racial groups are present in our gene discovery collections. In all previous disease gene discoveries in Utah , applicability to other populations has been conclusively proven.

  • The population is highly educated and enthusiastic about research and medical advances and the enthusiasm for our studies is particularly high among patients.

  • Families are generally well informed about their personal genealogy and family history.

Family members tend to be knowledgeable about their relatives and keep in touch with them. Family reunions and family newsletters are common.

  • The medical care in Utah and in the Intermountain West is centralized in the Salt Lake Metropolitan Area within 50 miles of Axial Biotech’s laboratories and it is of high quality, making confirmation of medical conditions easier.  

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